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Patent applications
 
  • Biocompatible thin films for dental implants made of titanium alloys, M.Braic, M.Balaceanu, V.Braic, A.Vladescu, OSIM no. A00776/29.10.2015

    • Published papers in ISI quoted journals

    Published papers

  • Mechanical, in vitro corrosion resistance and biological compatibility of cast and annealed Ti25Nb10Zr alloy, C.M. Cotrut, A.C. Parau, A.I. Gherghilescu, I. Titorencu, I. Pana, D. V. Cojocaru, V. Pruna, L. Constantin, I. Dan, D.M. Vranceanu, A. Vladescu, Metals, 7 (2017) 1-23, doi:10.3390/met7030086

  • Study on a hydrophobic Ti-doped hydroxyapatite coating for corrosion protection of titanium based alloy, M. Surmeneva,   A.Vladescu,   R.Surmenev,  C.M.Pantilimon,   M.Braic, C.M. Cotrut, RSC Advances, 6 (2016) 87665-87674

    The above mentioned paper was already cited in the following ISI quoted journals:

      • Applied Surface Science 413 (2017) 129-139(IF2016=3.387).
  • Influence of Ag content on the antibacterial properties of SiC doped hydroxyapatite coatings, M. Badea, M.Braic, A.Kiss, M.Moga, E.Pozna, I.Pana, A.Vladescu, Ceramics International, 42 (2016) 1801-181, doi:10.1016/j.ceramint.2015.09.143

    The above mentioned paper was already cited in the following ISI quoted journals:

      • Journal Of Alloys And Compounds 697(2017) 182-199 (IF2016=3.133).
      • Materials Science and Engineering C-Materials For Biological Applications 72 (2017) 472-480 (IF2016=4.164).
      • Nanotechnology Science And Applications 10 (2017) 1-9.
      • Ceramics International 43(2017) 992-1007 (IF2016=2.986).
      • Diamond and Related Materials 67(2016)54-62 (IF2016=2.125).
      • Journal of Microbiological Methods 125(2016)12-18 (IF2016=1.857).
      • Materials Science and Engineering C 62(2016)249-259 (IF2016=3.420).
  • Mechanical properties and biocompatibility of the sputtered Ti doped hydroxyapatite, A.Vladescu, S.C. Padmanabhan, F.Ak Azem, M.Braic, I.Titorencu, I.Birlik, M.A.Morris, V.Braic, Journal of the Mechanical Behavior of Biomedical Materials, 63 (2016) 314–325

    The above mentioned paper was already cited in the following ISI quoted journals:

      • Applied Surface Science 413 (2017) 129-139 (IF2016=3.387).
      • Applied Surface Science 401 (2017) 172-180 (IF2016=3.387).
  • Mechanical properties and fractal analysis of the surface texture of sputtered hydroxyapatite coatings, M.Bramowicz, M.Braic, F.Ak Azem, S.Kulesza, I.Birlik, A.Vladescu, Applied Surface Science, 379 (2016) 338-346, doi: 10.1016/j.apsusc.2016.04.077

    The above mentioned paper was already cited in the following ISI quoted journals:

      • Ceramics International 43(2017) 6858-6867  (IF2016=2.986).
      • Surface and Coatings Technology 316 (2017) 113-121 (IF2016=2.589).
      • Microscopy Research and Technique 79(2016) 1208-1213 (IF2016=1.130).
  • Effect of the deposition temperature on corrosion resistance and biocompatibility of the hydroxyapatite coatings, A. Vladescu, M. Braic, F. Ak Azem, I. Titorencu, V. Braic, V. Pruna, A. Kiss, A.C. Parau, I. Birlik, Applied Surface Science 354 (2015) 373-379

     

    Submitted papers

    • Sputtered Si and Mg doped hydroxyapatite for biomedical applications , A. Vladescu, C. M. Cotrut, F. A. Azem, I. Pana, V. Braic, I. Birlik, A. Kiss, M. Braic, R. Abdulgader, R. Booysen, T. K. Monsees, Biomedial Materials, 2017, under review

    • Ti- and Mg-doped hydroxyapatite coatings as possible candidates for orthopaedic implants ,T. K. Monsees, F. Ak Azem, C. M. Cotrut, M. Braic, R. Abdulgader, I. Pana, I. Birlik, A.Kiss, R. Booysen, A. Vladescu, Applied Surface Science, 2017 , under review
    • Biocompatible Materials Based on Self-Assembling Peptides on Ti25Nb10Zr Alloy: Molecular Structure and Organization, S.Franchi, V.Secchi, M.Santi, A.Vladescu, M.Braic, T.Skála, J. Lavkova, M.Dettin, A.Zamuner, G.Iucci, C.Battocchio, under review in Applied Surface Science 2017(FI2016= 3,387)
    • Biodegradable ceramics consisting of hydroxyapatite for orthopaedic implants,T. K. Monsees, F. Ak Azem, C. M. Cotrut, M. Braic, R. Abdulgader, I. Pana, I. Birlik, A.Kiss, R. Booysen, A. Vladescu, Coatings, 2017 , under review (FI2016= 2,175)

    Published papers in other international journals

  • Biocompatibility for bone tissue engineering of hydroxyapatite coated Ti6Al4V alloy containing an adhesive interlayer made of metallic carbides V. Pruna, A. M. Rosca, R. Tutuianu, A. Vladescu, V. Jinga, I. Titorencu, Buletinul Societatii Romane de Biologie Celulara 45 (2017) 74
  • Evaluation of the Ti-25Nb-10Zr alloy for possible application in the bone tissue engineering, V. Pruna, I. Titorencu, A. Vladescu, V.V. Jinga, Annals of the Romanian Society for Cell Biology 43 (2015) 69

    Books/Chapter of books

  • Radio frequency magnetron sputter deposition as a tool for surface modification of medical implants , R.A.Surmenev, A.Vladescu, M.A.Surmeneva, A.Ivanova, M.Braic, I.Grubova, C.M. Cotrut, InTECH-open science - 2017 in “Modern Technologies For Creating The Thin-Film Systems And Coatings”, EDS. N.Nikitenkov, A.M.A.Hashhash, http://dx.doi.org/10.5772/66396(ISBN 978-953-51-5056-5).

  • Surface engineering, C.M. Cotrut, A. Vladescu, S. Ciuca, D.M. Vranceanu, 2015, Ed.Tehnopress, Iasi, pp. 1-65 (ISBN 978-606-687-191-4)

  • Bioceramic Coatings for Metallic Implants in Handbook of Bioceramics and Biocomposites, A. Vladescu , M.A. Surmeneva , C.M. Cotrut , R.A. Surmenev , I.V. Antoniac, 2015, Springer International Publishing, pp 1-31, DOI: 10.1007/978-3-319-09230-0_31-1 (ISBN 978-3-319-09230-0)

    Submitted chapter of books for publishing

  • Ti-Nb-Zr system and its surface biofunctionalization for biomedical applications , M. Dinu, S. Franchi, V. Pruna, C. M. Cotrut, V. Secchi, M. Santi, I. Titorencu, C. Battocchio, G. Iucci, A. Vladescu, Elsevier - Titanium for Medical and Dental Applications_ A review of all aspects of titanium use in the medical and dental industries, 2017

  • Nanomaterials for medical applications and their antimicrobial advantages , A. Vladescu, M. Badea, S. C. Padmanabhan, G. Paraschiv, L. Floroian, L. Gaman, M. A. Morris, J. L. Marty, C. M. Cotrut Pharmaceutical Nanotechnology (I-XXVII) Multi-Volume SET – ELSEVIER 2017

    Attendees at international conferences

    Invited lectures

  • Functionalization of medical implants by biocomposite based hydroxyapatite coatings, A. Vladescu, Global Conference on Polymer and Composite Materials -PCM 2017, 23-25 May 2017, Guangzhou, China
  • Bioactive thin films for functionalization of dental and orthopaedic implants, A.Vladescu, 2nd International Young Scientists School „Nanostructured Materials”, 10 - 12 May 2016 Tomsk, Russia

    • Oral presentations

  • Improvement of the adhesion between hydroxyapatite and TI6AL4V alloy used for biomedical applications, M. Dinu, V. Pruna, M. Braic, C.M. Cotrut, I. Titorencu, I. Pana, V. Braic, A. Vladescu, New Trends on Sensing- Monitoring- Telediagnosis for Life Sciences- NT-SMT-LS, 7-9 September 2017, Bucharest, Romania.

  • Enhancement of antibacterial properties of sputtered, A.Vladescu, M.Badea, M.Braic, A.Kiss, M.Moga, V.Braic, E. Posna, M.Dinu, M.Balaceanu, E-MRS Spring meeting 2016, 2-6 May 2016, Lille, France.
  • Sputtered hydroxyapatite coatings used for enhancing the titanium based alloy osseointegration, A.Vladescu, I.Titorencu, V.Braic, A.Kiss, M.Braic, 6th International Conference on Materials Science and Technologies – RoMat 2016, 9-12 November 2016, Bucharest, Romania.

  • Investigation of the Ag doped hydroxyapatite as antibacterial coatings ,M.Dinu, M.Badea, M.Braic, A.Vladescu, M.Moga, V.Braic, E. Posna, A.Kiss, “7th International Conference “Biomaterials, Tissue Engineering & Medical Devices”-BIOMMEDD’2016, 15-17 September 2016, Constanta, Romania.
  • Ag and SiC doped hydroxyapatite coatings for biomaterial applications, A.Vladescu, M.Badea, M.Braic, A.Kiss, M.Moga, V.Braic, E. Posna, I.Pana, A.Parau, 9th International Conference on Materials Science & Encineering - BRAMAT 2015, 5-7 March 2015 Brasov, Romania 
  • Biofunctionalization of Ti based alloy by deposition of bioactive ceramic coatings,A.Vladescu, C.M. Cotrut, M. Braic, I. Dan, A. Kiss, V. Braic, S. Ivanescu,12th International Conference on Nanosciences & Nanotechnologies (NN15) 7-10  July 2015, Thessaloniki, Greece
  • Improvement of the mechanical and antibacterial properties of hydroxyapatite,A.Vladescu, M. Braic, M. Badea, A. Kiss, M. Dinu, M. Moga, V. Braic, E. Pozna,11th  Conference for Young Scientists in Ceramics, October 21-24, 2015, Novi Sad, Serbia
  • Calcium phosphate coatings deposited on Ti substrate using electrochemically assisted deposition,M. Vranceanu, A.I. Gherghilescu, A. Berbecaru, G. Tepes, C.M. Cotrut,11th  Conference for Young Scientists in Ceramics, October 21-24, 2015, Novi Sad, Serbia

    Posters presentations

  • Synthesis of sputtered SiC and Mg doped hydroxyapatite coatings for biomedical applications, D.M. Vranceanu, M. Dinu, F. Ak Azem, R. Abdulgader, V. Braic, I. Birlik, A. Kiss, C.M. Cotrut, R. Booysen, M. Braic, T.K. Monsees, A. Vladescu, E-MRS Spring meeting 2017, 22-26 May 2017, Strasbourg, France
  • TiO2 and MgO doped hydroxyapatite coatings as possible candidate for orthopaedic implants, A. Vladescu, M. Braic, M. Dinu, C. M.Cotrut, Global Conference on Polymer and Composite Materials -PCM 2017, 23-25 May 2017, Guangzhou, China.
  • Biological approaches to bone regeneration by tissue engineering and implantology, I. Titorencu; V.V. Jinga, V. Pruna, AM Rosca, C. Zaharia, M. Albu Kaya, A. Vladescu, M. Simionescu, First Annual Meeting, COST Action CA16119 CellFit, “In vitro 3-D total cell guidance and fitness”, 12-13 septembrie 2017, Albena, Bulgaria
  • Improvement of the adhesion between hydroxyapatite and Ti alloy substrate, A.Vladescu, A.Parau, A.I. Gherghilescu, D.M.Vranceanu, A.Kiss, I.Pana, C.M.Cotrut, 28th European Conference on Biomaterials, 4th – 8th September 2017, Athens, Greece.
  • In vitro biocompatibility and electrochemical behaviour of the Ti doped hydroxyapatite, A. Vladescu, M. Braic, A.Gherghilescu, A.Kiss, C. M. Cotrut, I.Titorencu, V.Jinga, V.Braic, E-MRS Spring meeting 2016, 2-6 May 2016, Lille, France.
  • Synthesis of bioactive coatings on Ti–25Nb–10Zr alloy for hard tissue implants, C.Cotrut, A.Vladescu, A.I.Gherghilescu, I.Titorencu, 10th World Biomaterials Congress (WBC), May 17-22, 2016, Montreal, Canada.
  • Novel biocompatible materials based on self-assembling oligopeptides anchored onto titanium alloys surfaces: molecular structure and organization, S. Franchi, A. Vladescu, V. Secchi, M. Santi, M. Braic, M. Dettin, G. Iucci, C. Battocchio, 13th International Conference on Nanosciences & Nanotechnologies (NN16) 5-8 July 2016, Thessaloniki, Greece
  • Fractal analysis of the surface texture of the hydroxyapatite coatings used for biomedical applications, A.Vladescu, L.Braic, I.Titorencu, V.Pruna, M.Dinu, “7th International Conference “Biomaterials, Tissue Engineering & Medical Devices”-BIOMMEDD’2016, 15-17 September 2016, Constanta, Romania.
  • Improvement of mechanical, anticorrosive and antibacterial properties of the hydroxyapatite coating, M.Dinu, M.Braic, M.Badea, I.Pana, A.Kiss, M.Moga, V.Braic, E. Posna, A.Vladescu, E-MRS 2015 Spring Meeting, 11-15 May 2015, Lille, France
  • Improvement of bioactivity of the TiZrNb alloy by deposition of CaP coatings, C.Vitelaru, A.Vladescu, M.Dinu, I.Pana, V.Braic, I.Dan, A.Kiss, M.Braic, S.Ivanescu, E-MRS 2015 Spring Meeting, 11-15 May 2015, Lille, France
  • Investigation of Ti25Nb10Zr alloy for orthopedic applications, I. Gherghilescu, C.M. Cotrut, I. Titorencu, I. Dan, S. Ivanescu, A. Vladescu, M. Braic, V. Pruna, V. Braic,12th International Conference on Nanosciences & Nanotechnologies (NN15) 7-10  July 2015, Thessaloniki, Greece
  • Synthesis and characterization of osseoconductive coatings deposited on Ti substrate, D.M. Vranceanu, A. Berbecaru, G. Tepes, A.I. Gherghilescu, A. Predescu, C.M. Cotrut, 12th International Conference on Nanosciences & Nanotechnologies (NN15) 7-10  July 2015, Thessaloniki, Greece
  • Enhancement of mechanical, anticorrosive and biological properties of hydroxyapatite by TiO2 addition, C.M. Cotrut, M. Braic, I. Titorencu, V. Braic, A. Kiss, I Pana, A. Vladescu, 12th International Conference on Nanosciences & Nanotechnologies (NN15) 7-10  July 2015, Thessaloniki, Greece
  • Enhancement of antibacterial properties of hydroxyapatite by Ag addition, A. Vladescu, V. Braic, M. Badea, M. Braic, M. Moga, A. Kiss, E. Pozna,12th International Conference on Nanosciences & Nanotechnologies (NN15) 7-10  July 2015, Thessaloniki, Greece
  • Improvement of antibacterial propertiez of hydroxyapatite coatings, A. Vladescu, M. Braic, M. Badea, A. Kiss, V. Braic,27th European Conference on Biomaterials (ESB 2015), 30 August-3 September, Krakow, Poland
  • Enhacement of osseoconductivity of Ti based alloys by bioactive calcium phospates coatings, C.M. Cotrut, I. Titorencu, A. Kiss, M. Tarcolea, F. Miculescu, D. Vranceanu, A. Vladescu,27th European Conference on Biomaterials (ESB 2015), 30 August-3 September, Krakow, Poland
  • Investigation of the hydroxyapatite coatings enriched with Ti, A. Gherghilescu, M. Dinu, A.Vladescu, M. Braic, C.M. Cotrut, V. Braic,„2nd International Conference – New Trends on Sensing – Monitoring – Telediagnosis for Life Sciences – NT-SMT-LS”, 2-5 September 2015, Brasov, Romania
  • Effect of the heat treatment on the sputtered hydroxyapatite coatings, A.I. Gherghilescu, A.Vladescu, A. Kiss, D.M. Vranceanu, M. Tarcolea, C.M. Cotrut,„6th International Conference on Advanced Materials and Structures (AMS'15)”, 15-17 October, 2015, Timisoara, Romania

    • Number of proposed projects in international consortia

  • Proposal entitled „Tailoring novel low-modulus Ti-based alloys with bioactive surfaces for regenerative medicine by means of advanced processing and characterization techniques (NIFREETiZrNb)” and submitted at „ERA.Net RUS Plus Call 2017 - Science & Technology”, in 04.07.2017, the current proposal status: under evaluation.
    1. Alina Vladescu – coordinator of INOE
    2. Cosmin M.Cotrut – partner of UPB
  • Proposal entitled „Nanoengineered metallic implant surfaces for tailored bioactive agent delivery (NanoimplantSurinfect)” and submitted at EURONANOMED2017-114” in 15.01.2017, but the proposal was not accepted for financing.
    1. Alina Vladescu – coordinator of INOE

  • Proposal entitled „Novel biofunctionalized surfaces for demanding medical applications (Bio4Medic)” and submitted at M-ERA.Net Call 2016” in 10.11.2016, but the proposal was not accepted for financing.
    1. Cosmin M.Cotrut – coordinator of UPB
  • Proposal entitled „Nanofunctionalization to induce osseointegration and to reduce the risk of infection (Surinfect)” and submitted at ERANETLAC JOINT CALL 2015-2016”-ELAC2015/T080496 in 10.03.2016, the project partners were from Romania, Argentina, Letonia, Brazil and Poland, but the proposal was not accepted for financing.
    1. Alina Vladescu – coordinator of INOE
  • Proposal entitled „New generation of biocompatible thin film metallic glasses (Coat4Bio)” and submitted at ERC Starting Grant 2017-H2020-ID:759543, but the proposal was not accepted for financing.
    1. Alina Vladescu – coordinator of INOE
  • Proposal entitled „Noi acoperiri multifunctionale cu proprietati bioactive, anticorozive si de degradare imbunatatite (DegraCoat)” and submitted at „Proiect experimental demonstrativ” in 17.06.2016, accepted for financing in january 2017:Ctr.117PED/2017.
    1. Alina Vladescu – partner of INOE
    2. Diana Vranceanu- coordinator of UPB
  • Proposal entitled „ Noi acoperiri multifuncționale cu posibile acțiuni antibacteriene și antifungice pentru imbunatatirea integrarii osoase a implanturilor” and submitted at „Proiect experimental demonstrativ” in 17.06.2016, but the proposal was not accepted for financing.
    1. Alina Vladescu – partner of INOE
  • Proposal entitled „Fabrication and investigation of new hybrid scaffolds with the controlled porous hierarchy for bone tissue engineering (INTELBIOCOMP)” and submitted at ERA.Net RUS Plus Joint Call for S&T projects-2014” in 25.09.2014, ID no. ERA.Net RUS Plus – S&T (Project ID # 58 – INTELBIOCOMP) accepted for financing in august 2015:Ctr.44/2016.
    1. Alina Vladescu – leader of INOE
    2. Cosmin M.Cotrut – leader of UPB
  • Proposal entitled „Nanostructured multifunctional materialsfor low wear artificial joints (NanoLOWear)” and submitted atERA.Net RUS Plus Joint Call for S&T projects-2014” in 25.09.2014, ID no. RUSPLUS_S&T-198,but the proposal was not accepted for financing.
    1. Alina Vladescu – coordinator of INOE
    2. Cosmin M.Cotrut – partener of UPB

    • Young people involved in the project:

    Researcher postdocs: A.Vladescu, C.Vitelaru, C.M.Cotrut, D.Vranceanu, M. Dinu

    PhD Students:  L. Constantin, I. Pana, A. Gherghilescu, V. Pruna

    Students: : D. Alexandru, M. V. Graure

    MsC students involved and supported

    MsC thesis:

  • Adelina-Elena Andries, "Enhancement of adhesion and tribological properties of hidroxyapatite coatings used for orthopedic applications", July 2017
  • Mihaela Violeta Graure, "Doped hydroxyapatite coatings with biocompatible metal carbides for improvement of mechanical properties", July 2016
  • Madalina Petre, "Corrosion resistance of the novel Ti alloy in various simulated biological solutions", July 2015
  • Constanta Negrila, "Enhancement of the mecahnical properties of Ti-based alloys consisting in biocompatible elements", July 2015
  • Andreea Grigore, "Bioactive coatings prepared by magnetron sputtering", July 2015

    • Vizibilitatea internationala a persoanelor implicate in proiect

    International visibility of the people involved in the project

    Alina Vladescu (director of the project):

    Cosmin Cotrut (P1 project responsible):

    Mariana Braic (member of the coordination team):

     



         

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